Researchers explored a new way to improve the health benefits of sour cherry extract, which is rich in natural anti-inflammatory compounds called polyphenols. These compounds can help with conditions like ulcerative colitis but are often unstable and hard for the body to absorb. To solve this, scientists combined sour cherry extract with a gentle, low-allergy pea protein. This combination not only made the cherry extract more stable during storage but also helped more of the beneficial compounds reach the small intestine during digestion. In tests using a model of ulcerative colitis, the protein-cherry complex—especially the version made in an acidic environment (called PSA)—reduced inflammation better than the cherry extract alone. It worked by calming an overactive immune pathway known as TLR4/NF-κB, which plays a big role in gut inflammation. The treatment helped protect the colon by reducing damage, shrinking inflammation, and preventing the colon from becoming too short—a sign of severe disease. Importantly, the protein-cherry complex also strengthened the gut’s protective barrier by boosting key proteins that keep the intestinal lining tight and healthy. This helped prevent harmful substances from leaking into the body and made symptoms less severe. Overall, the study shows that combining sour cherry extract with pea protein could be a promising, natural way to help manage ulcerative colitis and improve gut health. Ask ChatGPT
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